Machine learning is playing an ever-increasing role in biomedical research. Scientists at the Technical University of Munich (TUM) have now developed a new method of using molecular data to extract subtypes of illnesses. In the future, this method can help to support the study of larger patient groups.
In old age, the performance of the immune system decreases, and older people are more susceptible to infections. Research teams from Würzburg and Freiburg have now discovered an approach that could be used to slow down this process.
The German government is providing about 2.4 million Euros for a new research group in infectious diseases at JMU Würzburg. Dr. Carmen Aguilar will use this grant to search for new therapeutic approaches against one of the most common and recurrent bacterial infections.
Plants, fungi, and bacteria perceive blue light through photoreceptors. Light triggers photochemical reactions that control vital processes in cells. Researchers at the University of Bayreuth have now discovered that certain receptors do not necessarily require a specific glutamine, which was previously thought to be indispensable. Even without this glutamine, blue light can trigger crucial control signals in many organisms, albeit often with reduced efficiency. The results presented in Nature Communications make an important contribution to understanding the mechanisms of photoreceptors and their applications.
Life-like organ replicas - so-called 3D organoids - are a good way to research disease processes. A team from the University of Würzburg has now presented a kind of blueprint for such a model of the cervix.
Following a heart attack, the human body is incapable of repairing lost tissue due to the heart’s inability to generate new muscle. However, treatment with heart progenitor cells could result in the formation of functional heart cells at injured sites. This new therapeutic approach is introduced by an international team in Nature Cell Biology. The aim is to start clinical studies within the next two years.
Little is known about the food webs of herbivorous insects. A team from the Würzburg Biocenter is investigating, in Lower Franconia as well as in the Berchtesgaden Alps.
Inhibitory synapses in neuron cultures and brain tissue can now be visualized with ease and with high contrast. The newly developed synthetic affinity probe Sylite can be applied both for widefield and confocal 3D volumetric synapse visualization, for in-tissue inhibitory circuits mapping and for super-resolution imaging of synapses.
A low-cost and easy-to-manufacture lighting technology can be made with light-emitting electrochemical cells. Such cells are thin-film electronic and ionic devices that generate light after a low voltage is applied. Researchers at the Technical University of Munich (TUM) and the University of Turin have now used extensive data analysis to create first-class electrochemical cells from copper complexes that emit blue and white light.
Insect diversity is declining in Bavaria. Land use is a major driver, but the impact of climate change is still unknown. A study by the University of Würzburg has now investigated in more detail how both factors interact in driving insect diversity and what can be done to conserve it.
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