In stress situations, bacteria use special ion channels for defense. Understanding how they function provides the basis for combating harmful bacteria. A Würzburg research group in cooperation with ETH Zurich and the University of Oxford has now been able to decipher how two of these channels are structured and how they open up. The results were published in the renowned journal PNAS.
For a person to acquire immunity to a disease, T cells must develop into memory cells after contact with the pathogen. Until now, the number of cells that do this was believed to depend above all on the magnitude of the initial immune response. A team of researchers at the Technical University of Munich (TUM) has now called this into question.
Collaborative work of research groups at the University of Würzburg and the TU Dresden has provided important new insights for cancer research. During cell division specific target proteins have to be turned over in a precisely regulated manner. To this end specialized enzymes label the target proteins with signaling molecules. However, the enzymes involved in this process can also label themselves, thus initiating their own degradation. In a multidisciplinary approach, the researchers identified a mechanism of how enzymes can protect themselves from such self-destruction and maintain sufficient concentrations in the cell. These results have been published in the journal Science Signaling.
A research group from Würzburg has now been able to clarify the long-standing question of how the protein complex CDK-activating kinase (CAK), which controls the central processes of cell division and transcription, is activated. The group analyzed the active form of the protein/CAK complex and was able to decipher its function on a molecular level. These new findings provide the basis for further research on cancer drugs and were published in the renowned scientific journal PNAS.
The Technical University of Munich (TUM) is starting five new research projects that focus on the coronavirus and the search for new active ingredients. For example, the use of algorithms could ensure a more precise classification of the illness in the future. New therapeutic methods and the targeted prevention of the long-term effects will also be researched in other projects. The Bavarian Research Foundation (BFS) is funding the projects with around € 1.5 million.
The most important pathogenicity factors of the gastric pathogen Helicobacter pylori are centrally regulated by a small RNA molecule, NikS. And this was not the only surprise that NikS provided.
Researchers of the Technical University of Munich (TUM) have cultured so-called intestinal organoids from human intestinal tissue, which is a common byproduct when performing bowel surgery. These small “miniature intestines” can be used for molecular biological examinations and allow for a direct application of research results to humans, thereby making animal experiments redundant.