Biennial report of the Leibniz Institute for Food Systems Biology at the Technical University of Munich
With this bilingual report (German/English) we not only provide exciting insights into our science and research, but also report on important events in 2018 and 2019.
RCI and UKR scientists identified the transcription factor EGR2 as a major orchestrator of DNA methylation landscapes in human blood monocytes.
A new study carried out by a team of laser physicists, molecular biologists and physicians based at LMU Munich and the Max Planck Institute for Quantum Optics has confirmed the temporal stability of the molecular composition of blood in a population of healthy individuals. The data provide a basis for a new method of monitoring the constituents of blood and detecting alterations that reveal changes in a person’s state of health.
When airborne pollen levels are higher, increased SARS-CoV-2 infection rates can be observed. These results were determined by a large-scale study conducted by an international team headed by researchers at the Technical University of Munich (TUM) and the Helmholtz Zentrum München. Members of high-risk groups could protect themselves by watching pollen forecasts and wearing dust filter masks.
In the search for ways to effectively combat age-related human disease, the enzyme sirtuin 6 (Sirt6) has recently become a focus of biochemical research. A targeted activation of Sirt6 could prevent or mitigate such diseases, for example some types of cancer. In a paper for the journal "Nature Chemical Biology", biochemists from the University of Bayreuth have now shown how the small molecule MDL-801 binds to the enzyme Sirt6 and influences its activity. These findings stand to aid the development of new drugs.
An undesirable effect can occur in super-resolution fluorescence microscopy: photoblueing. A new publication in „Nature Methods“ shows how it can be prevented or made useful for research.
A new signaling pathway has been identified that can prevent the overproduction of certain RNA-protein complexes in neurons. These complexes play an important role in neurodegenerative diseases.
Researchers in the field of mathematics education at the University of Regensburg together with medical education researchers at the LMU University Hospital of Munich have found that medical diagnoses can be made more often correctly and even faster with the help of natural frequencies and natural frequency trees. The researchers explain their findings in a recently published article in Advances in Health Sciences Education.
With the help of artificial intelligence (AI) a German-American team of scientists deciphered some of the more elusive instructions encoded in DNA. Their neural network trained on high-resolution maps of protein-DNA interactions uncovers subtle DNA sequence patterns throughout the genome, thus providing a deeper understanding of how these sequences are organized to regulate genes.
Magnetic nanoparticles biosynthesized by bacteria might soon play an important role in biomedicine and biotechnology. Researchers of the University of Bayreuth have now developed and optimised a process for the isolation and purification of these particles from bacterial cells. In initial tests, magnetosomes showed good biocompatibility when incubated with human cell lines. The results presented in the journal "Acta Biomaterialia" are therefore a promising step towards the biomedical use of magnetosomes in diagnostic imaging techniques or as carrier in magnetic drug delivery applications.