“There won’t be a miracle cure for cancer,” says Thomas Brabletz. “A multi-faceted approach has to be taken to fighting cancer, which means that the most successful treatment strategy is likely to involve an intelligent combination of drugs, often tailored to the individual patient’s needs, that target various weaknesses.” Thomas Brabletz, a renowned cancer researcher, hopes to pinpoint these weaknesses, and is focusing on a relentless opponent that is still almost invariably fatal, even today and in spite of the major advancements made over recent years: metastatic cancer.
A team at the Technical University of Munich (TUM) has induced stem cells to emulate the development of the human heart. The result is a sort of “mini-heart” known as an organoid. It will permit the study of the earliest development phase of our heart and facilitate research on diseases.
For the second time, Würzburg cancer researcher Professor Martin Eilers has received one of the prestigious ERC Advanced Grants. The award is endowed with 2.5 million euros.
A research group from Würzburg led by Bernhard Nieswandt deciphered a platelet-mediated regulatory mechanism of fibrin formation in blood clotting opening the way to new therapeutic approaches. Hemostasis is vital to prevent excessive blood loss. However, there is an increased risk for thrombosis if there is an excessive reaction and uncontrolled formation of fibrin. In the study published in Nature Cardiovascular Research, the researchers uncover platelet glycoprotein GPV as a central regulator for hemostasis and thrombus formation.
Intestinal bacteria are often the trigger of complications after surgery. This is shown in a new study by research teams from Inselspital (University Hospital Bern), the University of Bern and the University of Würzburg. A solution to this problem could come from the liver.
When you hear the word microbiome, the chances are you will think of the gut. But the microbiome is so much more, namely the total of all microorganisms living on and in the human body. Skin, lungs or the digestive system, the mouth, throat, nose or the genital tract: they are all home to tiny living organisms such as bacteria, viruses or fungi. When the balance is correct, they are beneficial to human health. But what does the ideal microbiome look like? And what influence do quintillions of invisible organisms have on human health and disease?
Universitätsklinikum Erlangen is the first in the world to use CAR T-cells to successfully treat a patient suffering from a severe case of muscle inflammation (myositis). The disease is triggered by a malfunction in the immune system that leads to inflammation of the muscles, and the risk of developing a very severe form of the disease is high. The journal Lancet has now published news of the successful treatment in a case report.
Scientists at the University of Augsburg and Helmholtz Munich have made an important breakthrough in better understanding early processes in the development of type 2 diabetes by identifying a previously unknown transmission of messenger substances from adipose tissue to the pancreas. In a publication in Nature Communication, the team led by Prof. Dr. Kerstin Stemmer was able to show that adipose cells release tiny lipid membrane particles known as extracellular vesicles into the blood, which can stimulate the release of the blood sugar-lowering hormone insulin from the pancreas.
N-Heterocyclic compounds are central active ingredients of many drugs and at the same time important building blocks of new organic materials for the energy transition. Researchers at the University of Bayreuth, led by Prof. Dr. Rhett Kempe, now present in "Nature Communications" a concept for the rational design of new classes of substances belonging to the group of N-heterocyclic compounds. At the same time, they present two new classes of substances synthesized on the basis of this concept. Today, innovations in fields of medical agents or functional materials rely substantially on the discovery of new classes of substances.
Sophisticated mix of methods offers improved structure analysis - Young scientist from the University of Regensburg awarded the Lieselotte Templeton Prize of the German Crystallographic Society
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