The start-up Flux Polymers, which has its roots at the University of Würzburg, offers a simple and easy solution to keep plastic surfaces free of bacteria. Recently, it has found an investor and can now start its operational business.
The potassium channel KCNQ3 is required for our brain to generate accurate spatial maps. In mice, defects in KCNQ3 function have measurable effects on the internal navigation system. The findings of a research team including researchers from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) recently published in Nature Communications are also relevant for Alzheimer’s-type dementia research.
Why people suffer from chronic inflammatory bowel diseases (IBD) such as ulcerative colitis is only partially understood. However, it is known that the bacteria of the intestinal flora and dysfunction in the immune system play an important role. In patients with IBD, an increased number of cells in the intestinal wall, known as epithelial cells, die. Bacteria then pass from the interior of the intestine into the damaged intestinal wall, causing inflammation and further cell death. The epithelial barrier, the barrier between the intestinal contents and the intestinal wall also becomes more permeable.
It all started with joint pain and a red facial rash: the then 16-year-old Thu-Thao V had already undergone several medical examinations in three cities when she was diagnosed with systemic lupus erythematosus (SLE) in February 2017 at Universitätsklinikum Erlangen. In the life-threatening autoimmune disease, which mainly affects young women, the immune system attacks its own cells in various organ systems. After different immunosuppressive therapies failed to improve her symptoms, Thu-Thao V was treated with CAR-T cells by researchers from the German Centre for Immunotherapy (DZI) at Universitätsklinikum Erlangen in March 2021.
Healthy skin has a bacterial shield to protect against germs: the microbiome. This complex assembly of microorganisms was previously believed to be difficult to decipher. A team of researchers has now succeeded in using the enzyme benzonase to identify the living bacteria in skin swabs through sequencing. Their method opens up new possibilities for diagnosis and treatment in dermatology.
When the immune system attacks a person’s own intestines, this leads to chronic inflammation and considerable pain and discomfort for patients suffering from the disease. Together with researchers from the US and France, a team of researchers at Friedrich-Alexander Universität Erlangen-Nürnberg (FAU) has discovered a potential new approach to treatment. The results have been published in the journal Gastroenterology.
To date, there are no effective antidotes against most virus infections. An interdisciplinary research team at the Technical University of Munich (TUM) has now developed a new approach: they engulf and neutralize viruses with nano-capsules tailored from genetic material using the DNA origami method. The strategy has already been tested against hepatitis and adeno-associated viruses in cell cultures. It may also prove successful against corona viruses.
mRNA plays a key role in the conversion of genetic information from DNA to proteins. Their production is a delicate process. A research team at the University of Würzburg has now identified a crucial factor.
In addition to chemical factors, mechanical influences play an important role in the natural growth of human organs such as kidneys, lungs and mammary glands – but also in the development of tumors. Now a research team at the Technical University of Munich (TUM) has investigated the process in detail using organoids, three-dimensional model systems of such organs which are produced in the laboratory.
Newly Announced Federal and State Funding for Regensburg Center Opens New Era of Cutting Edge Research for Prestigious Medical Institute.