A new signaling pathway has been identified that can prevent the overproduction of certain RNA-protein complexes in neurons. These complexes play an important role in neurodegenerative diseases.
Autoimmune diseases, in which the body's own immune system attacks healthy tissue, can be life-threatening and can impact all organs. A research team at the Technical University of Munich (TUM) has now found a possible cause for these self-destructive immune system attacks: a hyperactive RANK protein on the surface of B cells. The research opens the door to new therapeutic possibilities.
A research team at the Technical University of Munich (TUM) has quantified the effects of an infection with the Human Immunodeficiency Virus (HIV) on the development of cervical cancer. Their results show that the risk of developing cervical cancer is six times higher in women who are infected with HIV. Southern and Eastern Africa are particularly affected.
Scientists from Würzburg and the US have charted the first global atlas of direct interactions between SARS-CoV-2 RNA and human host cells. This may provide a starting point for novel treatments.
All over the world, research into the development of a vaccine against the SARS-CoV2 virus is running at full speed - the breakthroughs of the last few days have made the headlines. Researchers from Fraunhofer EMFT and the University of Regensburg are working on a new assay concept that could speed up the evaluation of vaccine candidates and at the same time increase their significance.
The German Research Foundation (DFG) has approved three new Collaborative Research Centres/Transregios (CRC/TRR) at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU). The aim of CRC/TRR 305 is to understand the molecular mechanisms behind how metastases form and to develop new treatments for cancer metastases on this basis. In CRC/TRR 306, researchers will be investigating the collective behaviour of quantum systems. In the CRC ‘CLINT’, scientists will pursue a ground-breaking new approach in chemical reaction engineering to create technical catalysts with new properties.
More than 55 million people across the globe have contracted Covid-19, and 1.3 million have died as a result. Whilst most Covid-19 patients predominantly suffer from respiratory symptoms, the virus is not restricted to the respiratory tract, and can affect other organs as well. Often, the gastrointestinal tract is affected. A team led by Prof. Dr. Christoph Becker from Department of Medicine 1– Gastroenterology, Pneumology and Endocrinology at Universitätsklinikum Erlangen and a team from the Charité – Universitätsmedizin Berlin have discovered that there is a particularly high density of coronavirus docking sites in the gut epithelium.
For the first time ever, expansion microscopy allows the imaging of even the finest details of cell membranes. This offers new insights into bacterial and viral infection processes.
Viruses are infectious organic structures that spread by transmission and can only multiply within a suitable host cell. To understand how new viruses are created, it is necessary to determine the position of the individual genes precisely and comprehensively and to clarify what these genes do. A research team at the Technical University of Munich (TUM) has found a previously hidden gene that may have contributed to the unique biology of SARS-CoV-2 and thus to its rapid spread.
New complex for damage detection in DNA identified
Our body can repair damage to our DNA that can lead to the development of cancer by means of repair complexes. But how does the repair machinery recognize the damage? Scientists from the University of Würzburg and the University of Kent have now identified a complex that plays an important role in damage recognition in nucleotide excision repair. Due to its key position, the complex represents a starting point for research on cancer drugs. The results were published in the renowned journal Nucleic Acids Research.